Kyounghee Min

ETP-Specific Knockout Mice Reveal Endotrophin as a Key Regulator of Kidney Fibrosis in Ischemia-Reperfusion Injury Models

This study develops an ETP-specific knockout mouse model to demonstrate ETP's critical role in kidney fibrosis during ischemia-reperfusion injury.

HSD17B13 Couples Hepatocyte Lipid Metabolism to Stellate Cell Activation via TGFb-1 Signaling

This study identifies HSD17B13 as a dual metabolic and profibrotic effector that drives TGFb-1-dependent activation of hepatic stellate cells, linking lipid metabolism to fibrogenesis in MASH.

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

This study shows that MCT1 in hepatic stellate cells promotes collagen expression in NASH, while hepatocyte MCT1 does not significantly affect fibrosis.

Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice.

This study shows that targeting both DGAT2 in hepatocytes and FASN in stellate cells reduces NASH in mice more effectively than targeting either gene alone.

Paradoxical activation of SREBP1c and de novo lipogenesis by hepatocyte-selective ACLY depletion in obese mice.

The paper shows that ACLY depletion in obese mice paradoxically increases de novo lipogenesis despite reducing AcCoA levels, linked to increased SREBP1c expression.