Author

Chloe DiMarzio

University of Massachusetts Chan Medical School

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Mark KellyiD· 4 shared Michael CzechiD· 4 shared Batuhan YenilmeziD· 3 shared Kyounghee MiniD· 3 shared Anastasia KhvorovaiD· 2 shared Brianna M. BramatoiD· 2 shared Christopher B. NewgardiD· 2 shared Dimas EcheverriaiD· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersMolecular Biology

Mark KellyORCID

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4 papers

Recent·Most cited

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

Kyounghee Min, Batuhan Yenilmez, Mark Kelly, Dimas Echeverria, Michael Elleby, Lawrence M. Lifshitz, Naideline Raymond, Emmanouela Tsagkaraki, Shauna M. Harney, Chloe DiMarzio, Hui Wang, Nicholas McHugh, Brianna M. Bramato, Brett M. Morrison, Jeffery D. Rothstein, , Michael Czech

This study shows that MCT1 in hepatic stellate cells promotes collagen expression in NASH, while hepatocyte MCT1 does not significantly affect fibrosis.

eLife · Aug 31, 2023Peer-reviewedMolecular Biology

Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice.

Batuhan Yenilmez, Shauna M. Harney, Chloe DiMarzio, Mark Kelly, Kyounghee Min, Dimas Echeverria, Brianna M. Bramato, Samuel O. Jackson, Keith R. Reddig, Jason K. Kim, Anastasia Khvorova, Michael Czech

This study shows that targeting both DGAT2 in hepatocytes and FASN in stellate cells reduces NASH in mice more effectively than targeting either gene alone.

bioRxiv · Jul 5, 2023 · PreprintMolecular Biology

De novo lipogenesis fuels adipocyte autophagosome membrane dynamics

Leslie A. Rowland, Adı́lson Guilherme, Felipe dos Santos Henriques, Chloe DiMarzio, Nicole Wetoska, Mark Kelly, Keith R. Reddig, Gregory M. Hendricks, Meixia Pan, Xianlin Han, Olga Ilkayeva, Christopher B. Newgard, Michael Czech

This study identifies de novo lipogenesis as a critical source of fatty acids for autophagosome membrane dynamics in adipocytes, showing that Fasn deficiency impairs autophagy and p62 degradation.

bioRxiv · May 25, 2022 · PreprintMolecular Biology

Paradoxical activation of SREBP1c and de novo lipogenesis by hepatocyte-selective ACLY depletion in obese mice.

Batuhan Yenilmez, Mark Kelly, Guofang Zhang, Nicole Wetoska, Olga Ilkayeva, Kyounghee Min, Leslie A. Rowland, Chloe DiMarzio, Wentao He, Naideline Raymond, Lawrence M. Lifshitz, Meixia Pan, Xianlin Han, Jun Xie, Randall H. Friedline, , Michael Czech

The paper shows that ACLY depletion in obese mice paradoxically increases de novo lipogenesis despite reducing AcCoA levels, linked to increased SREBP1c expression.

bioRxiv · Mar 21, 2022 · PreprintMolecular Biology