Michael Czech

HSD17B13 Couples Hepatocyte Lipid Metabolism to Stellate Cell Activation via TGFb-1 Signaling

This study identifies HSD17B13 as a dual metabolic and profibrotic effector that drives TGFb-1-dependent activation of hepatic stellate cells, linking lipid metabolism to fibrogenesis in MASH.

Thermogenic adipocytes alleviate hepatic steatosis and insulin resistance via macrophage cytokine secretion in obese mice

This study shows that adipocyte Nrip1 deficiency in obese mice reduces hepatic steatosis and insulin resistance by promoting M2-like macrophages that secrete IL-1rn.

A dominant CIDEC variant segregates with familial obesity by increasing lipid droplet size in adipocytes

This study identifies a dominant CIDEC variant causing familial obesity by increasing lipid droplet size in adipocytes through structural and functional changes.

Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose de novo lipogenesis

This study identifies PTHrP as a driver of pancreatic cancer cachexia by suppressing adipose de novo lipogenesis, showing that blocking PTHrP-PTH1R signaling reduces wasting in mouse models.

The autophagy receptor Ncoa4 controls PPARγ activity and thermogenesis in brown adipose tissue

This study identifies Ncoa4 as a regulator of PPARγ activity and thermogenesis in brown adipose tissue through genetic and functional analyses.

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

This study shows that MCT1 in hepatic stellate cells promotes collagen expression in NASH, while hepatocyte MCT1 does not significantly affect fibrosis.

Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice.

This study shows that targeting both DGAT2 in hepatocytes and FASN in stellate cells reduces NASH in mice more effectively than targeting either gene alone.

De novo lipogenesis fuels adipocyte autophagosome membrane dynamics

This study identifies de novo lipogenesis as a critical source of fatty acids for autophagosome membrane dynamics in adipocytes, showing that Fasn deficiency impairs autophagy and p62 degradation.

Paradoxical activation of SREBP1c and de novo lipogenesis by hepatocyte-selective ACLY depletion in obese mice.

The paper shows that ACLY depletion in obese mice paradoxically increases de novo lipogenesis despite reducing AcCoA levels, linked to increased SREBP1c expression.

Cold-Induced Thermogenesis Increases Acetylation on the Brown Fat Proteome and Metabolome

The paper identifies proteomic and metabolic changes in brown fat tissue in response to cold exposure, highlighting increased acetylation and lipid synthesis.