Andrew G. Jamieson

The paper designs and characterizes triazole-based peptidomimetics of the -GI conotoxin, showing they retain potency and provide structural insights into their interaction with the muscle-type nAChR.

This study demonstrates that inhibiting VP2-mediated entry reduces calicivirus infectivity, suggesting a potential antiviral strategy for treating norovirus disease.

The paper determines the molecular basis of -conotoxin specificity for muscle-type nAChRs using cryo-EM structures and computational methods.

This study shows that inhibiting PfCLK3 disrupts RNA-splicing in malaria parasites, affecting 1125 genes and providing a novel mechanism for a radical cure.

This study identifies PfCLK3 as a druggable target for malaria by showing its essential role in multiple parasite life stages across species.