Daniel A. Llano

This study establishes and validates an awake longitudinal fUS-ULM-fULM framework in mice over five months, showing no significant longitudinal drift and no memory impairment or chronic neuroinflammation.

The paper identifies task-dependent modulation in the mouse dorsal cortex of the inferior colliculus, showing distinct response classes and their dependence on movement and auditory cortex activity.

This study shows that MOV10 loss in mice leads to enhanced fear learning through altered cortical connectivity and increased GABRA2 expression, suggesting new mechanisms for fear memory and potential therapeutic targets.

This study introduces a novel behavioral paradigm to assess threat discrimination and shows that oxytocin-modulated translational control stabilizes threat-safety discrimination, with disruptions leading to generalized avoidance in Tuberous Sclerosis Complex.

This study investigates chronic ZIKV infection in adults using neuroimaging, finding no significant brain changes associated with long-term infection.

The paper modifies a GAD-GFP mouse line to reduce hearing loss and validates its improved auditory function and GFP expression in GAD+ neurons.

This paper uses microprism-based two-photon imaging to study the mouse inferior colliculus lateral cortex, revealing distinct functional properties of its structural motifs in response to auditory and somatosensory stimuli.

This paper introduces a combined imaging technique using ultrasound localization microscopy and nanodrop imaging to detect intracerebral hemorrhage in rodent models.

The paper examines branching patterns of layer 5 and 6 auditory corticofugal axons in mice, finding they have complementary distributions and extensive branching.

This study shows that developmental PCB exposure impairs recovery from noise-induced hearing loss and disrupts auditory midbrain organization in mice.

This study identifies tinnitus-related changes in synaptic function of specific neuronal subtypes in an animal model, showing increased excitability in pyramidal and VIP neurons that correlate with tinnitus behavior.

This study uses ultrasound localization microscopy to image cerebrovascular impairments in a mouse model of Alzheimer's disease, finding early functional vascular changes precede structural derangements.

This study uses Ultrasound Localization Microscopy to quantify aging-related changes in cerebral microvascular dynamics in living mice, finding reduced blood velocity, increased tortuosity, and decreased blood volume in the cortex.

The paper investigates corticothalamic gating of auditory thalamocortical transmission in mice, finding that corticothalamic feedback inhibition controls population responses to sensory stimuli.

This study applies a novel network analysis tool, CommDy, to aging mouse brain imaging data, revealing fragmented cortical networks and altered synaptic connectivity in aged brains.

This study shows that developmental PCB exposure causes lasting changes in inhibitory and excitatory neurotransmission in the rat auditory cortex, independent of peripheral hearing loss.

V-NeuroStack is a visualization tool for analyzing calcium imaging data from mouse cortical neurons, enabling exploration of spatio-temporal patterns through 3D time stacks and 2D networks.

The paper investigates serum lipidomic profiles in Alzheimer Disease patients with and without hearing loss, finding altered phosphatidylcholine levels associated with hearing loss.

This study shows that adding VGF peptide levels to conventional biomarkers improves prediction of conversion from mild cognitive impairment to Alzheimer's Disease.

This study uses computational modeling to show that open-loop thalamo-reticulo-thalamic synaptic motifs support cortical signal propagation better than closed-loop configurations.

The paper investigates how auditory and somatosensory inputs are processed in the mouse inferior colliculus, finding that GABAergic neurons in modules link distinct processing streams.

The paper identifies differences in origin and termination patterns between layer 5 and layer 6 corticocollicular neurons in the mouse auditory system.

The paper identifies a novel 4-marker CSF and MRI signature for predicting Alzheimer's disease progression, reinforcing the 2018 NIA-AA framework with improved accuracy over conventional markers.

The paper identifies distinct cortical and thalamic input patterns in layer 5 and 6 auditory corticocollicular neurons in mice, highlighting their different roles in modulating the inferior colliculus.

This paper introduces a novel mutual information estimator for spike train correlations in a thalamocortical network and shows it outperforms existing methods in analyzing simulated and electrophysiological data.