Prerana Shrestha

This study introduces a novel behavioral paradigm to assess threat discrimination and shows that oxytocin-modulated translational control stabilizes threat-safety discrimination, with disruptions leading to generalized avoidance in Tuberous Sclerosis Complex.

This study identifies a molecular clock in the prelimbic cortex that regulates protein synthesis for memory consolidation and reconsolidation through distinct translational pathways.

The paper investigates the role of the TSC-Rheb axis in Oxytocin receptor+ cells in stress-induced anxiety, finding sex-specific behavioral and neural changes in TSC mutant mice.

This paper introduces Opto4E-BP, an optogenetic tool that inhibits translation initiation in specific cell types and times, showing it blocks long-term memory consolidation.

This study shows that de novo protein synthesis in specific CeL interneurons is required for storing threat memories and response inhibition.

The paper develops a chemogenetic tool to inhibit protein synthesis in specific neurons and shows it is required for long-term memory consolidation.