K. Saidas Nair

PRSS56 acts as an intrinsic retinal signal driving postnatal ocular axial growth and myopia susceptibility

This study identifies PRSS56 as a retinal factor promoting ocular axial growth and links it to myopia susceptibility through genetic and functional analyses.

Tyr is Responsible for the Cctq1a QTL and Links Developmental Environment to Central Corneal Thickness Determination

The paper identifies Tyr as the gene responsible for the Cctq1a QTL and shows that developmental light exposure interacts with genotype to influence central corneal thickness.

GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans

This study shows GLIS1 regulates trabecular meshwork function and intraocular pressure, with a human variant linked to glaucoma.

A multiethnic GWAS meta-analysis of 585,243 individuals identifies new risk loci associated with cataract and reveals sex-specific effects

This study identifies 54 new genetic risk loci for cataract through a multiethnic GWAS meta-analysis and finds sex-specific effects and gene expression relevance in mouse models.

Genetic background modifies vulnerability to glaucoma related phenotypes in Lmx1b mutant mice

This study shows that genetic background affects the severity of glaucoma-related phenotypes in Lmx1b mutant mice, identifies a modifier locus on Chromosome 18, and provides strains with varying phenotypes.

Identification of ADAMTS19 as a novel retinal factor involved in ocular growth regulation

The paper identifies ADAMTS19 as a retinal factor that compensates for impaired ocular growth in PRSS56 and MFRP mutant mice, highlighting its role in axial length regulation.

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer's disease

PRSS56 is required for the developmental positioning of ocular angle structures

This study shows that PRSS56 is essential for proper positioning of ocular angle structures during development, leading to angle closure and elevated intraocular pressure in mice.