Iván Manuel

This paper synthesizes and characterizes UVI3502, a novel CB1 receptor antagonist/inverse agonist, showing high affinity for CB1 and low affinity for CB2, with potential interactions with GPR55.

This study shows that WIN55,212-2 prevents scopolamine-induced spatial memory impairment by increasing cannabinoid receptor density and muscarinic tone in cortical areas.

This study shows that CB1 agonist WIN55,212-2 improves memory and increases cortical ACh and choline-containing lipids in cholinergic lesion models.

The paper defines lipid profiles for five brain cell types and maps their spatial distribution using mass spectrometry imaging.

The paper compares S1P1 receptor activity in human, rat, and mouse brains using autoradiography, finding high activity in grey matter regions and suggesting rats as a suitable model for human studies.