bioRxivNeurosciencePreprint
Cell lipotypes localization in brain by mass spectrometry imaging
Jonatan Martínez‐GardeazabaliD, Marta Moreno‐RodrígueziD, Alberto Llorente‐OvejeroiD, Estíbaliz González de San RomániD, Laura LombarderoiD, Iker Bengoetxea de TenaiD, Juan SustachaiD, Carlos MatuteiD, Iván ManueliD, Paolo BonifaziiD, Rafael Rodríguez‐PuertasiD
Abstract
The study investigates brain lipid super-specialisation by defining characteristic spectral lipotypic profiles for the five primary cerebral cell-types. Utilizing a computational approach, the research visualizes the anatomical distribution of these profiles with high spatial resolution in brain tissues. This method unveils cellular stereotypic lipidic signatures within the CNS, providing a new framework for exploring the physiological roles of lipids in diverse cell-types present in brain or in any other tissue.
- organism: human
- assay: metabolomics
- research focus: spatial domain detection
- approach: statistical model
- Citations
- 1
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