Longhua Guo

The paper develops a serum-free 6iL/E4 culture system that enables derivation and maintenance of embryonic stem cells (ESCs) across multiple mammalian species, revealing conserved mechanisms for ESC self-renewal.

Regeneration in aging planarians reverses age-related physiological and molecular changes, restoring youthful gene expression and tissue composition.

This paper characterizes a new planarian isolate, Girardia sp. (Guanajuato), at morphological, cellular, and molecular levels to identify unique traits and facilitate future comparisons.

The paper identifies a mutation in leopard geckos causing white coloration and tumors, linking it to a tumor suppressor gene.

The paper identifies chromosome 1 in Schmidtea mediterranea as a sex-primed autosome through genomic analysis showing restricted recombination and sex-specific gene expression.

The paper maps eQTLs at cellular resolution in C. elegans using single-cell RNA sequencing, revealing cell-type-specific and single-cell-specific eQTL effects.

The paper introduces V-seq, a cost-effective method for viral genome sequencing that uses multiplexed RT primers to improve coverage and reduce costs.

The paper identifies a nuclear hormone receptor and lipid metabolism axis critical for reproductive organ maintenance and regeneration in planarians.

This paper develops a simple and adaptable chromosome preparation protocol for invertebrates, enabling karyotyping and downstream applications in species lacking cell lines.