Author

Jacob M. Tome

Cornell UniversityORCID 0000-0001-5107-2766Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Research Focus:variant calling· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jay ShendureiD· 2 shared John T. LisiD· 2 shared Alexis DziubekiD· 1 shared Allison CotéiD· 1 shared Andria Ellis· 1 shared Anh Leith· 1 shared Anran HuangiD· 1 shared Arjun RajiD· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersGenomics

Jay ShendureORCID

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4 papers

Recent·Most cited

Molecular BiologybioRxivPreprintOct 30, 2021

CTCF blocks anti-sense transcription initiation at divergent gene promoters

Jing Yuan Luan, Camille M. Syrett, Marit Willemijn Vermunt…·Gerd A. Blobel

The paper shows CTCF suppresses antisense transcription at divergent promoters without affecting sense transcription, using a combination of genetic and molecular techniques.

5 citations

humanbulk RNA-seq

𝕏 PostBluesky

GenomicsbioRxivPreprintSep 30, 2020

TransMPRA: A framework for assaying the role of many trans-acting factors at many enhancers

Diego Calderon, Andria Ellis, Riza M. Daza…·Jay Shendure

TransMPRA combines CRISPR perturbation and MPRAs to identify trans-acting factors influencing enhancer activity.

13 citations

experimental assay

𝕏 PostBluesky

GenomicsbioRxivPreprintAug 15, 2020

Rapid cost-effective viral genome sequencing by V-seq

Longhua Guo, James Boocock, Jacob M. Tome…·Yi A. Yin

The paper introduces V-seq, a cost-effective method for viral genome sequencing that uses multiplexed RT primers to improve coverage and reduce costs.

9 citations

metagenomicslong-read sequencing

𝕏 PostBluesky

GenomicsbioRxivPreprintMay 18, 2020

✦ In-depth digest

A rapid, sensitive, scalable method for Precision Run-On sequencing (PRO-seq)

Julius Judd, Luke Wojenski, Lauren M. Wainman…·Leighton J. Core

A precision run-on sequencing (PRO-seq) variant with one streptavidin bead binding and on-bead enzymatic steps yields adapter-ligated cDNA in about 10 h and libraries from 0.05–0.25 × 10^6 cells.

69 citations

humanChIP-seq

𝕏 PostBluesky