The paper identifies a dual-domain mechanism in the Flower protein that coordinates extracellular vesicle-mediated fitness selection and cell-intrinsic survival in astrocytes, with implications for Alzheimer's disease.

1 citation

humanmouse

𝕏 PostBluesky

NeurosciencebioRxivPreprintJun 22, 2020

Flower initiates a positive feedback loop upon PIP2 enrichment at periactive zones to control bulk endocytosis

Tsai-Ning Li, Yu-Jung Chen, You-Tung Wang…·Chi‐Kuang Yao

The paper shows that Flower and PIP2 interact to control activity-dependent bulk endocytosis through a positive feedback loop.

DOI 10.1101/2020.06.22.164400

experimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintMay 30, 2020

Dynamin-2 regulates synaptic podosome maturation to facilitate neuromuscular junction development

Shan‐Shan Lin, Tsung-Lin Hsieh, Gunn‐Guang Liou…·Ya‐Wen Liu

This study identifies Dyn2's role in postsynaptic morphogenesis by regulating synaptic podosome turnover and actin cytoskeleton organization in Drosophila NMJs.

DOI 10.1101/2020.05.30.125062

Drosophilaexperimental assay

𝕏 PostBluesky