Dual-domain Flower signaling coordinates extracellular vesicles-mediated fitness selection and cell-intrinsic survival in astrocytes
Szu-Min Tu, Ching-Hsin Lin, Yang Liu, Claudia Schirra, Chin-An Yang, Johannes Hohneck, Martin Jung, Annika Clemenz, Sandra Rother, Ahmad Aljohmani, Daniela Yildiz, Yvonne Schwarz, Elmar Krause, Walter Schulz‐Schaeffer, Veit Flockerzi, , Hsin‐Fang Chang
The paper identifies a dual-domain mechanism in the Flower protein that coordinates extracellular vesicle-mediated fitness selection and cell-intrinsic survival in astrocytes, with implications for Alzheimer's disease.
bioRxiv · Aug 8, 2025 · PreprintNeuroscience