This study shows that Ddx3x is essential for B-cell development in mice, with loss leading to developmental blocks and defects in immunoglobulin rearrangement.

bioRxiv · Nov 28, 2025 · PreprintImmunology

Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland

Mandi M. Wiley, Marcin Radziszewski, Bhuwan Khatri, Michelle L. Joachims, Kandice L. Tessneer, Anna M. Stolarczyk, Songyuan Yao, James Li, C. Pritchett Frazee, Audrey A. Johnston, Astrid Rasmussen, Juan‐Manuel Anaya, Lara A. Aqrawi, Sang‐Cheol Bae, Eva Baecklund, , Christopher J. Lessard

The paper identifies five SNPs in the DDX6-CXCR5 locus associated with autoimmune diseases and shows their functional effects on gene regulation in immune and epithelial cells.

Annals of the Rheumatic Diseases · May 29, 2025Peer-reviewedGenetics

Mitochondrial Dysfunction and Fatigue in Sjögren's Disease

Biji T. Kurien, John A. Ice, Rebecca Wood, Gavin A. Pharaoh, Joshua W. Cavett, Valerie Lewis, Shylesh Bhaskaran, Astrid Rasmussen, Christopher J. Lessard, Amy Darise Farris, Kathy Sivilis, Kristi A. Koelsch, Holly Van Remmen, Robert Hal Scofield

This study investigates mitochondrial dysfunction and its link to fatigue in Sjögren's disease by analyzing T cell metabolism and mitophagy transcriptional signatures.

RMD Open · Apr 1, 2025Peer-reviewedImmunology