Author

Shylesh Bhaskaran

OU Health Stephenson Cancer CenterORCID 0000-0002-0651-2299Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Albert Tran· 2 shared Chao JiangiD· 2 shared Constantin GeorgescuiD· 2 shared Courtney W. HoucheniD· 2 shared Jonathan D. WreniD· 2 shared Michael T KinteriD· 2 shared Phoebe Ohene-MarfoiD· 2 shared Sabira MohammediD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Albert Tran

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Hepatocyte MLKL Drives Obesity-Driven Hepatocellular Carcinoma Progression via Mitochondrial Dysfunction Independent of Necroptosis in MASLD

Phoebe Ohene-Marfo, Sabira Mohammed, Chao Jiang, Shylesh Bhaskaran, Kara Kneuper, Satoshi Matsuzaki, Bo Hagy, Randal J. May, Constantin Georgescu, Megan John, Julianne N. Hoang, Kevin Pham, Albert Tran, Chinthalapally V. Rao, Tae Gyu Oh, , Sathyaseelan S. Deepa

This study shows that hepatocyte MLKL promotes obesity-driven MASLD-HCC through mitochondrial dysfunction and MFN2 suppression, independent of necroptosis.

Hepatology · Aug 4, 2026Peer-reviewedCancer Biology

A Non-canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

Sabira Mohammed, Chao Jiang, Travis Pennington, Shylesh Bhaskaran, Phoebe Ohene-Marfo, Kara F. Kneuper, Constantin Georgescu, Kamille Pitts, Albert Tran, Zongkai Peng, Amit Singh, Zhibo Yang, Tiangang Li, Bethany N. Hannafon, Courtney W. Houchen, , Sathyaseelan S. Deepa

This study shows that MLKL in hepatocytes promotes liver aging by inducing senescence and mitochondrial dysfunction without causing necroptosis.

Aging Cell · Jul 1, 2026Peer-reviewedCell Biology

Mitochondrial Dysfunction and Fatigue in Sjögren's Disease

Biji T. Kurien, John A. Ice, Rebecca Wood, Gavin A. Pharaoh, Joshua W. Cavett, Valerie Lewis, Shylesh Bhaskaran, Astrid Rasmussen, Christopher J. Lessard, Amy Darise Farris, Kathy Sivilis, Kristi A. Koelsch, Holly Van Remmen, Robert Hal Scofield

This study investigates mitochondrial dysfunction and its link to fatigue in Sjögren's disease by analyzing T cell metabolism and mitophagy transcriptional signatures.

RMD Open · Apr 1, 2025Peer-reviewedImmunology