Author

Christopher W. Brownlee

Stony Brook UniversityORCID 0000-0003-1045-4033Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:development & morphogenesis· 3 Assay:proteomics· 3 Organism:Xenopus· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Organism:human· 1

Frequent Co-Authors

Natalie MosquedaiD· 2 shared Patrick James SuttoniD· 2 shared Guadalupe E. Pena· 1 shared Lauren K. Slevin· 1 shared M. Kathryn MaloneiD· 1 shared Rebecca HealdiD· 1 shared Xiaohong ZhouiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

7 top collaborators · 7 mutual co-author links

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2 shared papersCell Biology

Natalie MosquedaORCID

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 1, 2026

Palmitoylated importin α recruits PKCε to the plasma membrane to drive breast cancer cell motility

M. Kathryn Malone, Christopher W. Brownlee

DOI 10.64898/2026.05.28.728515

humanproteomics

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Cell BiologyEMBO ReportsPeer-reviewedMay 27, 2025

Palmitoylated Importin α Regulates Mitotic Spindle Orientation Through Interaction with NuMA

Patrick James Sutton, Natalie Mosqueda, Christopher W. Brownlee

This study shows that palmitoylated importin α localizes NuMA to the cell cortex, regulating mitotic spindle orientation and preventing microcephaly in Xenopus laevis.

4 citations

Xenopusexperimental assay

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Cell BiologyCytoskeletonPeer-reviewedMay 6, 2025

Identification of a motif in TPX2 that regulates spindle architecture in Xenopus egg extracts

Guadalupe E. Pena, Xiaohong Zhou, Lauren K. Slevin…·Rebecca Heald

The paper identifies a conserved NLS motif in TPX2 that regulates astral microtubule formation and spindle pole morphology in Xenopus egg extracts.

1 citation

Xenopusproteomics

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Cell BiologybioRxivPreprintApr 10, 2025

A Role for Importin α in Ciliogenesis and Cilia Length Regulation during Nephrogenesis

Natalie Mosqueda, Patrick James Sutton, Christopher W. Brownlee

This study shows importin α is involved in ciliogenesis and cilia length regulation during kidney development in Xenopus laevis.

DOI 10.1101/2025.04.10.648263

Xenopusproteomics

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