Rebecca Heald

The paper shows that TOPBP1-dependent DNA damage processing leads to CENP-A loss and centromere destabilization in inviable Xenopus hybrids.

This study shows that spindle scaling enables adaptation to polyploidy by modulating microtubule dynamics and architecture across different ploidy levels.

This study investigates how ploidy and neuron size affect nervous system development and function in Xenopus by analyzing triploid tadpoles and their physiological and behavioral differences.

This study shows that the nuclear-cytoplasmic ratio affects the cell cycle period in frog egg extracts, with nuclei increasing in size and extending the cycle time.

The paper shows CK2 inhibition shifts spindle morphology from meiotic to mitotic-like in Ciona and Xenopus, suggesting CK2 regulates RanGTP-driven microtubule nucleation during fertilization.

The paper identifies a conserved NLS motif in TPX2 that regulates astral microtubule formation and spindle pole morphology in Xenopus egg extracts.

This study uses optimized expansion microscopy to reveal species-specific differences in spindle microtubule organization between Xenopus laevis and Xenopus tropicalis.

The paper quantifies single-molecule diffusivity in Xenopus egg extracts to reveal the cytoplasm's physicochemical properties, showing charge-dependent diffusion and the role of RNA and actin.

The paper presents high-quality genomes and chromatin structure analyses of frogs, revealing conserved ancestral chromosomes and stable genome evolution.

The paper compares size metrics in embryos from different ploidy Xenopus species, including the dodecaploid X. longipes, revealing distinct size scaling regimes during development.

This study identifies and characterizes centromeric sequences in Xenopus laevis using CENP-A ChIP-seq and k-mer analysis, revealing diverse repeat sequences and mapping centromere positions on each chromosome.

The paper investigates size control in Xenopus hybrids by analyzing gene expression and its impact on embryonic development and body size.