Author

Zhiyi Sun

New England Biolabs (United States)ORCID 0000-0003-1063-0471Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:E. coli· 1

Frequent Co-Authors

Erbay YigitiD· 1 shared Hoong Chuin LimiD· 1 shared Ira SchildkrautiD· 1 shared Irem ÜnlüiD· 1 shared Marina K. SmileyiD· 1 shared Matthew J. SzucsiD· 1 shared Nan DaiiD· 1 shared Tien-Hao Chen· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

Erbay YigitORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 19, 2026

Adenosine Deamination by HPAMPD Reveals Structural Constraints on Adenosine Accessibility in RNA

Matthew J. Szucs, Tien-Hao Chen, Zhiyi Sun…·Ira Schildkraut

This study shows that HPAMPD deaminates RNA adenosines preferentially at terminal ends and in loop regions, influenced by structural features like base pairing and magnesium-dependent folding.

DOI 10.64898/2026.10.16.759644

bulk RNA-seqexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintAug 18, 2025

Massively Parallel Screens Reveal Factors Influencing the Activity of a Diversity-Generating Retroelement Reconstituted in Escherichia coli

Irem Ünlü, Marina K. Smiley, Vladimir Potapov…·Hoong Chuin Lim

The paper identifies cellular factors influencing DGR activity in E. coli through reconstitution and screens, revealing mutagenic contexts and orientation preferences that enhance editing efficiency.

DOI 10.1101/2025.08.18.670894

E. coliDNA methylation

𝕏 PostBluesky