Ira Schildkraut

This study shows that HPAMPD deaminates RNA adenosines preferentially at terminal ends and in loop regions, influenced by structural features like base pairing and magnesium-dependent folding.

The paper determines the structure of HPAMPD, a mollusk adenosine deaminase with nucleotide specificity, and shows how it binds the 5-monophosphate group of AMP through specific structural elements.

This study introduces NRCeq, a method to identify capped full-length SARS-CoV-2 transcripts, revealing new insights into sgRNA structure and expression.

ReCappable-seq identifies TSS for all RNA polymerases at single-nucleotide resolution, revealing novel TSS in nuclear and mitochondrial genomes and expanding understanding of non-Pol-II transcription.

This study introduces MetaGPA, a framework linking metagenomic genetic data to functional phenotypes, and identifies a novel cytosine modification mechanism in DNA and RNA.

The paper identifies high-confidence full-length human RNA isoform scaffolds using nanopore sequencing by improving 5' cap detection and 3' polyadenylation site identification.

This study characterizes the yeast DcpS enzyme's ability to decap long RNA transcripts and validates its use for enriching capped RNA through a tagging strategy.

The paper introduces Cappable-seq, a method that identifies transcription start sites at single base resolution in E. coli and a mouse gut microbiome.