Mahmood Reza Amiry-Moghaddam

This study uses two-photon imaging to show that mitophagy decreases with age in mouse somatosensory cortex neurons and astrocytes, with astrocytes showing higher mitophagy levels than neurons, and NAD+ treatment improves mitophagy in aged mice.

The paper investigates fibrotic scarring in CNS lesions across species and lesion types, finding pericyte-derived fibrosis as a conserved mechanism.