Philippe Collas

Multimodal epigenetic and enhancer network remodeling shape the transcriptional landscape of beige adipocytes

The paper identifies epigenetic and enhancer network changes during beige adipocyte formation, linking them to transcriptional shifts and metabolic function.

Loss of multi-level 3D genome organization during breast cancer progression

This study investigates how 3D genome organization changes during breast cancer progression using Hi-C and epigenomic data, revealing structural alterations linked to oncogenic gene activation.

Mechanisms of sexually dimorphic adipose tissue remodelling upon prolonged breastfeeding

This study investigates how prolonged breastfeeding affects adipose tissue remodeling in mice, revealing sex-dependent mechanisms that influence tissue expansion and function.

Eight principal chromatin states functionally segregate the fly genome into developmental and housekeeping roles

The paper identifies eight chromatin states in Drosophila that segregate the genome into developmental and housekeeping roles through chromatin protein and histone mark associations.

De novo annotation of lncRNA HOTAIR transcripts by long-read RNA capture-seq reveals a differentiation-driven isoform switch

The paper uses long-read RNA capture-seq to annotate HOTAIR transcripts in human adipose stem cells, revealing a differentiation-driven isoform switch.

TAD cliques predict key features of chromatin organization

The paper identifies TAD cliques as repressive chromatin domains with distinct structural and functional features across cell types.

Rhythmic chromatin interactions with lamin B1 reflect stochasticity in variable lamina-associated domains during the circadian cycle

The paper identifies rhythmic chromatin interactions with lamin B1 in mouse liver during the circadian cycle, showing that periodic LADs are stochastic and not linked to gene expression rhythms.

Cohesin facilitates zygotic genome activation in zebrafish

This study shows that cohesin is essential for zygotic genome activation in zebrafish by redistributing to active genes and influencing chromosome architecture.