Mateusz Wojciech Kucharczyk

The paper uses single-nucleus RNA sequencing to identify five distinct classes of anterolateral system neurons in the adult mouse spinal cord and their laminar distribution.

This study identifies the origin of diffuse noxious inhibitory controls (DNIC) by showing that optogenetic manipulation of brainstem noradrenergic neurons modulates pain thresholds in a pro-pain manner.

The paper investigates brainstem to spinal cord noradrenergic pathways and their differential effects on spinal neuronal activity through optogenetic activation.

The paper demonstrates stage-specific plasticity in spinal neuronal modulation by descending controls in a rodent model of cancer-induced bone pain, with implications for stage-specific therapeutic targeting.

This study investigates how bone cancer affects the peripheral encoding of mechanical pressure stimuli by comparing sensory afferent responses in healthy and cancer-induced bone pain rats.