Author

Callan P. O’Shea

Yale UniversityORCID 0000-0003-1096-1983Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:Hi-C· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Schahram AkbarianiD· 3 shared Aditi ValadaiD· 2 shared Kristen BrennandiD· 2 shared Marina IskhakovaiD· 2 shared Rahat Elahi· 2 shared Samuel K. PowelliD· 2 shared Tova Y. LambertiD· 2 shared Will LiaoiD· 2 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

Schahram AkbarianORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintJul 17, 2023

Schizophrenia Risk Mapping and Functional Engineering of the 3D Genome in Three Neuronal Subtypes

Samuel K. Powell, Will Liao, Callan P. O’Shea…·Kristen Brennand

The paper maps 3D chromatin structures in neuronal subtypes and shows how schizophrenia risk loci reorganize during differentiation, linking regulatory loops to gene function.

2 citations

humanChIP-seq

𝕏 PostBluesky

NeuroscienceMolecular CellPeer-reviewedDec 1, 2022

HIV integration in the human brain is linked to microglial activation and 3D genome remodeling

Amara L. Plaza-Jennings, Aditi Valada, Callan P. O’Shea…·Schahram Akbarian

The paper examines HIV integration in the human brain using single nuclei transcriptomics, Hi-C, and IS-seq, finding 3D genomic reorganization and microglial activation linked to HIV infection.

40 citations

humanscRNA-seq

𝕏 PostBluesky

NeuroscienceMolecular PsychiatryPeer-reviewedSep 7, 2021

Induction of Dopaminergic Neurons for Neuronal Subtype-Specific Modeling of Psychiatric Disease Risk

Samuel K. Powell, Callan P. O’Shea, Kayla G. Townsley…·Kristen Brennand

This study develops a method to efficiently generate dopaminergic neurons from hiPSCs and shows they model psychiatric disease risk genes.

31 citations

humanbulk RNA-seq

𝕏 PostBluesky