Tova Y. Lambert

This study examines how HIV and substance use disorders affect gene expression in human ventral midbrain neurons and microglia, identifying transcriptional changes linked to disease comorbidities.

The paper analyzes single nucleus transcriptomics data from opioid overdose cases and controls to show widespread glial activation and changes in gene expression related to substance use traits.

The paper examines HIV integration in the human brain using single nuclei transcriptomics, Hi-C, and IS-seq, finding 3D genomic reorganization and microglial activation linked to HIV infection.

This study develops a method to efficiently generate dopaminergic neurons from hiPSCs and shows they model psychiatric disease risk genes.