Roy Maimon

This paper develops a multimodal spatial transcriptomics approach to study CAG repeat expansion, huntingtin aggregation, and neuron loss in Huntington's Disease using human brain tissue.

MERFISHEYES provides a web-based platform for visualizing and sharing spatial transcriptomics data, enabling interactive exploration and cross-dataset comparisons.

This paper demonstrates that transient suppression of PTBP1 in aged glial cells can re-activate neurogenesis in murine and human brains, generating new neurons through canonical pathways.

This study identifies TDP-43 dysfunction and reduced m6A modification as mechanisms causing aberrant splicing in Huntington's disease using mouse and human brain data.

This study shows CRMP2 is essential for Sema3F-dependent axon pruning and dendritic spine remodeling, linking its dysfunction to ASD-like behaviors in mice.

The paper identifies a novel retrograde death signal mechanism in ALS motor neurons involving CRMP4-dynein complex formation triggered by muscle-secreted Sema3A.