Martin Balaštík

This study shows that reduced microtubule polyglutamylation causes neuronal dysfunction and worsens Tau-induced neurodegeneration in mice.

This study shows that tau phosphorylation impairs the protective function of tau envelopes, leading to microtubule destabilization in neurodegenerative disorders.

The paper shows that polyglutamylation of microtubules regulates neuronal remodeling by marking them for severing, affecting synapse and axon pruning in both peripheral and central circuits.

This paper shows FKBP12 inhibits CRMP2A-mediated microtubule polymerization and axon growth by binding to unphosphorylated CRMP2A.

This study shows CRMP2 is essential for Sema3F-dependent axon pruning and dendritic spine remodeling, linking its dysfunction to ASD-like behaviors in mice.

The paper identifies a novel retrograde death signal mechanism in ALS motor neurons involving CRMP4-dynein complex formation triggered by muscle-secreted Sema3A.