Author
Hospital for Sick ChildrenORCID 0000-0003-1119-590XUnclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Rebekah Tillotson, Marina Gertsenstein, Li‐Hsin Chang…·Monica J. Justice
This study shows that crispant founder mice can be used for phenotypic assessment despite genetic mosaicism, as observed null phenotypes were present in up to 100% of founders.
Hillary Elrick, Kevin A. Peterson, Brandon Willis…·Valerie Laurin
The paper analyzes 3,313 genetically engineered mouse lines to identify gene essentiality as the main factor affecting Cas9-based genome editing success.
Kevin A. Peterson, Sam Khalouei, Nour Hanafi…·Lauryl M. J. Nutter
The paper analyzes whole-genome sequencing data from Cas9-edited mice to assess off-target mutagenesis, finding minimal off-target activity across 163 guide RNAs.
Pilar Cacheiro, Carl Henrik Westerberg, Jesse Mager…·John Pullinger
The paper identifies novel Mendelian genes by analyzing mouse embryo lethality and linking them to human disease phenotypes and genetic variants.