Jaqueline Hersch-González

The paper compares phenotypic and transcriptomic differences between a tropical wild C. elegans strain, the N2 Ancestral strain, and the domesticated N2 Bristol strain, revealing regulatory divergence due to domestication.

This study shows that transient high glucose exposure induces persistent transcriptional and chromatin changes in endothelial cells, which can be reversed by NRF2 pathway activation.