Shengzhou Wu

This study shows APOE4 worsens Aβ oligomer-induced synaptotoxicity by promoting autophagic degradation of STIM1 and Gpx4, leading to mitochondrial dysfunction and synaptic loss.

This study shows that inhibiting serine racemase with L-ABH prevents diabetic retinopathy by protecting retinal cells and maintaining glucose homeostasis in diabetic mice.

This study shows that Dicer1 promotes Aβ clearance by increasing APOE through blocking B2 RNA-mediated APOE mRNA degradation in AD mice.

This study shows Dicer1 is reduced in AD mouse models and regulated by Nrf2, with overexpression improving spatial learning and reducing oxidative stress.