Author

Michael Ruesch

The Ohio State UniversityORCID 0000-0003-1156-455XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Aharon G. FreudiD· 3 shared Hongchuan LiiD· 2 shared Paul W. Wright· 2 shared Stephen K. AndersoniD· 2 shared Ansel NaliniD· 1 shared Anthony G MansouriD· 1 shared benjamin kraemer· 1 shared Bethany L Mundy-BosseiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersDevelopmental Biology

Aharon G. FreudORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintNov 4, 2026

CD200R1 Marks a Branchpoint During Human Natural Killer Cell Development in Tonsils

Youssef Youssef, Ansel Nalin, Michael Ruesch…·Aharon Freud

The paper identifies CD200R1 as a marker for an immature NK-cell precursor in tonsils, distinguishing between oligopotent and more restricted developmental stages.

DOI 10.64898/2026.11.02.762613

humanscRNA-seq

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Developmental BiologybioRxivPreprintNov 8, 2024

Cell fate determination is associated with changes in competing transcriptional units in the human GATA1 and GATA2 lineage-determining transcription factors

Erik M Anderson, Hongchuan Li, Michael Ruesch…·Stephen K. Anderson

The paper examines the ratio of sense and antisense transcripts of GATA1 and GATA2 in human progenitors and leukemia cell lines, showing that promoter competition influences cell fate decisions during differentiation.

DOI 10.1101/2024.11.08.622131

humanbulk RNA-seq

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Developmental BiologyCell ReportsPeer-reviewedNov 1, 2023

Evidence for the digital programming of cellular differentiation: characterization of binary switches in lineage-determining transcription factors

Hongchuan Li, Md Ahasanur Rahman, Michael Ruesch…·Stephen K. Anderson

The paper identifies binary promoter switches in lineage-determining transcription factors, showing mutually exclusive sense/antisense transcription and distinct gene expression patterns in different cell states.

6 citations

humanscRNA-seq

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