Hongchuan Li

Lineage-specific chromatin poising enforced by ETS-IRF composite elements determines the divergent interferon responses of plasmacytoid dendritic cells and epithelial cells

This paper identifies lineage-specific chromatin accessibility differences at IFN gene loci in pDCs and epithelial cells, revealing ETS-IRF composite elements as key regulators of divergent interferon responses.

CRISPR-Based Gene Dependency Screens reveal Mechanism of BRAF Inhibitor Resistance in Anaplastic Thyroid Cancer

This study identifies TAZ deficiency as synthetically lethal with BRAF inhibitors in anaplastic thyroid cancer, revealing a mechanism of resistance and a potential therapeutic target.

Cell fate determination is associated with changes in competing transcriptional units in the human GATA1 and GATA2 lineage-determining transcription factors

The paper examines the ratio of sense and antisense transcripts of GATA1 and GATA2 in human progenitors and leukemia cell lines, showing that promoter competition influences cell fate decisions during differentiation.

Evidence for the digital programming of cellular differentiation: characterization of binary switches in lineage-determining transcription factors

The paper identifies binary promoter switches in lineage-determining transcription factors, showing mutually exclusive sense/antisense transcription and distinct gene expression patterns in different cell states.