Author

Stephen K. Anderson

Frederick National Laboratory for Cancer ResearchORCID 0000-0002-7856-4266Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Hongchuan LiiD· 3 shared Aharon G. FreudiD· 2 shared Michael RueschiD· 2 shared Paul W. Wright· 2 shared Adam Lacy‐HulbertiD· 1 shared Adelle P. McFarlandiD· 1 shared Caprice D. Eisele· 1 shared Chunhua YaniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersDevelopmental Biology

Hongchuan LiORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintJun 10, 2026

Lineage-specific chromatin poising enforced by ETS-IRF composite elements determines the divergent interferon responses of plasmacytoid dendritic cells and epithelial cells

Gargi Mishra, Snehal Ozarkar, Yo Okamura…·Ram Savan

This paper identifies lineage-specific chromatin accessibility differences at IFN gene loci in pDCs and epithelial cells, revealing ETS-IRF composite elements as key regulators of divergent interferon responses.

1 citation

humanATAC-seq

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Developmental BiologybioRxivPreprintNov 8, 2024

Cell fate determination is associated with changes in competing transcriptional units in the human GATA1 and GATA2 lineage-determining transcription factors

Erik M Anderson, Hongchuan Li, Michael Ruesch…·Stephen K. Anderson

The paper examines the ratio of sense and antisense transcripts of GATA1 and GATA2 in human progenitors and leukemia cell lines, showing that promoter competition influences cell fate decisions during differentiation.

DOI 10.1101/2024.11.08.622131

humanbulk RNA-seq

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Developmental BiologyCell ReportsPeer-reviewedNov 1, 2023

Evidence for the digital programming of cellular differentiation: characterization of binary switches in lineage-determining transcription factors

Hongchuan Li, Md Ahasanur Rahman, Michael Ruesch…·Stephen K. Anderson

The paper identifies binary promoter switches in lineage-determining transcription factors, showing mutually exclusive sense/antisense transcription and distinct gene expression patterns in different cell states.

6 citations

humanscRNA-seq

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