Cell fate determination is associated with changes in competing transcriptional units in the human GATA1 and GATA2 lineage-determining transcription factors
Erik M Anderson, Hongchuan Li, Michael Ruesch, Paul W. Wright, Aharon G. Freud, Stephen K. Anderson
The paper examines the ratio of sense and antisense transcripts of GATA1 and GATA2 in human progenitors and leukemia cell lines, showing that promoter competition influences cell fate decisions during differentiation.
bioRxiv · Nov 8, 2024 · PreprintDevelopmental Biology