Author

Katherine A. Spoth

University at Buffalo, State University of New YorkORCID 0000-0003-1168-5829Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:electronic health records· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Assay:cryo-EM· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Matthew R. CrawleyiD· 2 shared Michael W. MartynowycziD· 2 shared Purna Chandra Rao VasireddyiD· 2 shared Charlie DubbeldamiD· 1 shared Daniel SerwasiD· 1 shared David Anthony MulleriD· 1 shared Denver R. Hopkins· 1 shared Devrim Acehan· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

Matthew R. CrawleyORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 27, 2026

Correcting Multiple Scattering Enables Dynamical Electron Crystallography in Standard Workflows

Denver R. Hopkins, Tim Low-Beer, Zhiyuan Ding…·Michael W. Martynowycz

GROND improves electron crystallography by correcting multiple scattering, enhancing refinement accuracy and revealing hidden structural details in various materials.

DOI 10.64898/2026.10.24.761591

electronic health recordsexperimental assay

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BiophysicsNature CommunicationsPeer-reviewedFeb 14, 2026

Direct from the Seed: An Atomic-Resolution Protein Structure by Ab Initio MicroED

Purna Chandra Rao Vasireddy, Timothy C. Low-Beer, Katherine A. Spoth…·Michael W. Martynowycz

The paper solves an atomic-resolution protein structure using ab initio microED from spontaneously formed nanocrystals, achieving 0.85 Å resolution and resolving individual hydrogen atoms.

1 citation

electronic health recordsexperimental assay

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Cell BiologyNature MethodsPeer-reviewedSep 23, 2025

Dose-Efficient Cryo-Electron Microscopy for Thick Samples using Tilt-Corrected Scanning Transmission Electron Microscopy, Demonstrated on Cells and Single Particles

Yue Eric Yu, Katherine A. Spoth, Michael Colletta…·Lena Fitting Kourkoutis

This paper introduces tilt-corrected bright-field scanning-TEM (tcBF-STEM) for cryo-EM, showing improved contrast and efficiency for thick samples, with a subnanometer resolution SPA map of a virus-like particle.

60 citationstop 1%

bacteria (other)cryo-EM

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