Mantre Dehnad

This study compares the neurophysiological and molecular recovery from isoflurane anesthesia with sleep and sleep deprivation in mice, finding distinct gene expression patterns and EEG features.

The paper links hippocampal oscillatory activity during memory encoding to distinct molecular programs in anterior and posterior hippocampus using single-nucleus RNA sequencing and spatial transcriptomics.

The paper shows that stimulation increases firing rates in pyramidal cells and strengthens cell assemblies in the human temporal cortex, linked to gene networks involving excitatory neurons and non-neurons.

The paper shows sleep loss alters glutamatergic synaptic properties in the neocortex, which are reversed by sleep, and links these changes to sleep-related genes and MEF2c/HDAC4 regulation.