Robert W. Greene

This study compares the neurophysiological and molecular recovery from isoflurane anesthesia with sleep and sleep deprivation in mice, finding distinct gene expression patterns and EEG features.

The paper shows sleep loss alters glutamatergic synaptic properties in the neocortex, which are reversed by sleep, and links these changes to sleep-related genes and MEF2c/HDAC4 regulation.

This study identifies norepinephrine transporter reversal as a mechanism for LC-dependent dopamine release in the dorsal hippocampus, enhancing synaptic strength and memory formation.

This study identifies MEF2C as essential for the biological responses to sleep loss, including gene expression changes and synaptic strength recovery.