Author

Gaëlle Carrat

Imperial College LondonORCID 0000-0003-1189-3441Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Alejandra TomásiD· 1 shared Ben J. JonesiD· 1 shared Guy A. RutteriD· 1 shared Isabelle LeclerciD· 1 shared Muthukumaran NatarajaniD· 1 shared Piero MarchettiiD· 1 shared Pradeep Kumar Shahi· 1 shared Rajamannar Thennati· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

Alejandra TomásORCID

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1 paper

Recent·Most cited

Pharmacology & ToxicologyDiabetes Obesity and MetabolismPeer-reviewedAug 20, 2025

Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion in vitro and in vivo of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001

Yusman Manchanda, Ben J. Jones, Gaëlle Carrat…·Guy A. Rutter

This paper describes the synthesis and properties of a novel dual GLP-1R/GIPR agonist, HISHS-2001, showing improved pharmacological profile compared to tirzepatide in vitro and in vivo.

4 citations

mouseexperimental assay

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