This study shows that high expression of FLP recombinase in C. elegans causes synaptic trafficking defects, highlighting potential cytotoxicity of tyrosine recombinases at high doses.

DOI 10.64898/2026.10.01.756008

C. elegansexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintJun 12, 2026

Activity-Dependent Postsynaptic Mitochondrial ROS Signaling Drives Avoidance Plasticity in C. elegans

Kaz M. Knight, Zephyr Lenninger, Ennis W. Deihl…·Frédéric J. Hoerndli

This paper shows that activity-dependent mitochondrial ROS signaling in C. elegans drives avoidance plasticity by enhancing synaptic strength and circuit function.

DOI 10.64898/2026.06.05.730457

C. elegansexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintAug 11, 2022

A Dual Role for LAR-RPTP in Regulating Long-distance Transport and Synaptic Retention of AMPARs, Essential for Long Term Associative Memory

D.M. Pierce, Zephyr Lenninger, Rachel L. Doser…·Frédéric J. Hoerndli

This study shows that PTP-3A regulates AMPAR transport and synaptic retention in C. elegans, essential for long-term associative memory.

1 citation

C. elegansexperimental assay

𝕏 PostBluesky