Luka Culibrk

This study identifies heterogeneous roles of APOBEC3A and APOBEC3B in lung adenocarcinoma mutagenesis using CRISPR-Cas9 and whole-genome sequencing of single-cell clones.

This paper introduces UDSeq, a duplex sequencing protocol for accurate somatic mutation detection with low DNA input and high coverage, achieving a low error rate and enabling cross-species profiling.

DupCaller improves mutation detection in duplex sequencing by using sample-specific error profiles and a strand-aware model, increasing sensitivity across various samples and conditions.

The paper uses long-read sequencing to analyze HPV integration sites in cervical cancer genomes, identifying structural and epigenetic impacts of integration.

This paper presents a long-read sequencing dataset of cancer samples, showing its ability to resolve structural variants, haplotypes, and methylation patterns in precision medicine.

IMPALA detects allele-specific expression in cancer samples and identifies potential regulatory mechanisms influencing ASE.

The paper describes the development of CIViCmine, a text-mining tool that extracts clinically relevant cancer biomarkers from literature to aid curation into the CIViC database.

This study identifies somatic coding and regulatory variants in DLBCL, revealing novel mechanisms of oncogene deregulation and potential therapeutic targets.