Author

Alex James McDonald

Baylor College of MedicineORCID 0000-0003-1214-3562Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:imaging· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

François St-PierreiD· 4 shared Gregory ForaniD· 3 shared Haixin LiuiD· 3 shared Jacob ReimeriD· 3 shared Jonathan BradleyiD· 3 shared Jun ZhuiD· 3 shared Laurent BourdieuiD· 3 shared Mario GaldameziD· 3 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

François St-PierreORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintJul 27, 2026

A highly Ca2+-permeable channelrhodopsin from the ancyromonad Nutomonas longa enables optogenetic control of Ca2+ signaling

Elena G. Govorunova, Yueyang Gou, Alex James McDonald…·John L. Spudich

This paper identifies NlCCR, a channelrhodopsin from Nutomonas longa, which enables precise optical control of Ca2+ signaling with improved properties compared to existing tools.

DOI 10.64898/2026.07.22.740102

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintJun 3, 2026

A red-emitting, genetically encoded indicator for two-photon voltage recording in vivo

Shuyuan Yang, Alex James McDonald, Xiaoyu Lu…·François St-Pierre

This paper introduces VADER1, a red GEVI that enables reliable in vivo two-photon voltage imaging with millisecond resolution and supports dual-color imaging with calcium indicators.

1 citation

experimental assay

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NeuroscienceNature MethodsPeer-reviewedApr 15, 2026

Designer indicators for two-photon recording of subthreshold voltage dynamics

Michelle Ann Land, Mario Galdamez, Vincent Villette…·François St-Pierre

The paper develops two new genetically encoded voltage indicators (JEDI3sub and JEDI3hyp) for improved two-photon recording of subthreshold voltage dynamics in vivo.

6 citationstop 1%

mouseimaging

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NeurosciencebioRxivPreprintApr 10, 2026

A versatile, positive-going voltage indicator that enables accessible two-photon recordings in vivo

Alex James McDonald, Michelle Ann Land, S. Q. Yang…·François St-Pierre

The paper introduces FORCE1s, a GEVI that enables robust two-photon voltage imaging in awake mice with high signal-to-noise and reliable spike detection.

3 citations

mouseimaging

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