This paper introduces VADER1, a red GEVI that enables reliable in vivo two-photon voltage imaging with millisecond resolution and supports dual-color imaging with calcium indicators.

bioRxiv · Jun 3, 2026 · PreprintNeuroscience

Designer indicators for two-photon recording of subthreshold voltage dynamics

Michelle Ann Land, Mario Galdamez, Vincent Villette, Jun Zhu, Xiaoyu Lu, Mate Marosi, Shuyuan Yang, Gregory Foran, Alex James McDonald, Xiaoyu Dong, Elsayed Zaabout, Haixin Liu, Zhuohe Liu, Kevin L. Colbert, Shujuan Lai, , François St-Pierre

The paper develops two new genetically encoded voltage indicators (JEDI3sub and JEDI3hyp) for improved two-photon recording of subthreshold voltage dynamics in vivo.

Nature Methods · Apr 15, 2026Peer-reviewedNeuroscience

A versatile, positive-going voltage indicator that enables accessible two-photon recordings in vivo

Alex James McDonald, Michelle Ann Land, S. Q. Yang, Noura Hakam, Vincent Villette, Jun Zhu, Mario Galdamez, Mario Fernández de la Puebla, Xiaoyu Lu, Gregory Foran, Tanmayee Torne-Srivastava, Beatriz Campillo, Haixin Liu, Xiaoyu Dong, Shujuan Lai, , François St-Pierre

The paper introduces FORCE1s, a GEVI that enables robust two-photon voltage imaging in awake mice with high signal-to-noise and reliable spike detection.

bioRxiv · Apr 10, 2026 · PreprintNeuroscience

Notch signalling plays a critical role in patterning the ventral mesoderm during early embryogenesis in Drosophila melanogaster

Marvel Megaly, Gregory Foran, Arsala Ali, Anel Turgambayeva, Tai Sengsouriya, Samantha Berube, Ryan Douglas Hallam, Ping Liang, Aleksandar Necakov

The paper investigates the role of Notch signaling in ventral mesoderm patterning during early Drosophila embryogenesis and identifies genes regulated by this pathway.

International Journal of Molecular Sciences · Jan 27, 2026Peer-reviewedDevelopmental Biology