Charles H. Yoon

TRACE identifies tumor-reactive CD8+ T cells across solid tumors using clonotype-level classification and scRNA-seq data, showing high accuracy and specificity for tumor-experienced T cells.

Slide-tags enables spatial localization of single nuclei for multi-modal spatial genomics, achieving high-resolution mapping and multiomic profiling in various tissues.

The paper develops a toolbox for scRNA-Seq and snRNA-Seq of fresh and frozen human tumors, testing it across eight tumor types and optimizing protocols for different tissue characteristics.