John B. Cole

The paper presents CattleGTEx, a resource characterizing regulatory effects in cattle, resolving GWAS signals and providing insights into adaptive evolution and selection.

GSOR and MTAO detect widespread cis-regulatory effects on bovine complex traits by linking gene expression with genetic scores and multi-trait associations.

The paper constructs a cattle Genotype-Tissue Expression atlas and identifies genetic regulatory variants linked to gene expression and traits in cattle.

The paper identifies a frameshift mutation in IFT80 causing embryonic lethality in Holstein cattle and validates it using CRISPR-Cas9 knockout embryos.

The paper performs GWAS and fine-mapping on seven health traits in Holstein cattle to identify genetic variants and candidate genes associated with health outcomes.

The paper imputes sequence variants in Holstein bulls and performs fine-mapping of 35 traits using a Bayesian approach, identifying candidate genes and variants.

This study simulates how gene editing impacts dairy cattle breeding programs by reducing harmful allele frequencies and inbreeding.