T. Reid Alderson

The paper identifies a histidine switch that regulates pH-responsive self-assembly of a helical protein filament through electrostatic interactions.

The paper maps the functional landscape of the human intrinsically disordered proteome using evolutionary signatures to classify and predict IDR functions.

This study identifies a histidine switch in C9CARD that regulates pH-dependent filament formation through electrostatic interactions and structural changes.

This study shows PARP1 condensates partition DNA repair proteins and enhance DNA ligation through PARylation-dependent mechanisms.

The paper investigates how cardiac stress regulates Filamin C dimerisation through phosphorylation-modulated interactions with HSPB7, revealing evolutionary conservation of this mechanism.