Yiwei Zhang

The paper identifies re-polyadenylation of maternal mRNA degradation intermediates during mammalian oocyte-to-embryo transition using PAIso-seq data across species.

This study shows mitochondrial mRNA is a stable reference for RNA-seq normalization, outperforming exogenous spike-ins and reducing batch effects.

The paper introduces a new method to analyze poly(A) tail composition and length, revealing conserved and variable features across eukaryotic species.

This study compares poly(A) tail dynamics during oocyte-to-embryo transition across four mammalian species, identifying conserved and divergent features of maternal mRNA regulation.

The paper introduces mRNA degradation intermediates as a simple indicator of mRNA and cell metabolism, validated in mouse and human cell lines and oocytes.

The paper introduces MePAIso-seq2, a method to study m6A, alternative splicing, and poly(A) tailing, finding m6A affects splicing but not polyadenylation site choice and is associated with longer poly(A) tails.