Hu Nie

This study identifies impaired maternal mRNA deadenylation as a molecular defect in in vitro matured mouse and human oocytes, leading to abnormal gene expression.

This study shows that non-A residues in poly(A) tails enhance mRNA translation efficiency in mouse and human cells, offering a new approach to improve mRNA-based therapeutics and vaccines.

The paper identifies re-polyadenylation of maternal mRNA degradation intermediates during mammalian oocyte-to-embryo transition using PAIso-seq data across species.

This study identifies the dynamic roles of non-A residues in poly(A) tails during mouse oocyte-to-embryo transition, showing their impact on mRNA stability and degradation.

The paper introduces a new method to analyze poly(A) tail composition and length, revealing conserved and variable features across eukaryotic species.

The paper quantifies poly(A) tail length dynamics during the mammalian oocyte-to-embryo transition and shows their role in maternal gene expression across species.

The paper introduces mRNA degradation intermediates as a simple indicator of mRNA and cell metabolism, validated in mouse and human cell lines and oocytes.

The paper profiles poly(A) tail dynamics in human oocytes and embryos, revealing dynamic changes in length and non-A residues, and identifies mechanisms for their regulation.