Prasenjit Bhaumik

This study shows endosulfan disrupts Hedgehog signaling by altering GSK3β activity, leading to ciliopathy-like effects in mice and linking to human reproductive disorders.

This study shows endosulfan, a pesticide, suppresses hedgehog signaling by activating GSK3β and repressing GLI-regulated genes, mimicking genetic ciliopathies.

This study models the structure and simulates the membrane binding and pore formation mechanism of PfPLP1, revealing how it interacts with host cell membranes and forms pores.

This study identifies glucose-tolerant variants of a fungal β-glucosidase through site-specific mutations, improving its industrial applicability by enhancing glucose tolerance and kinetic properties.

This study structures and engineers Omega transaminases from Pseudomonas putida to improve their efficiency in converting (R)-Phenylacetylcarbinol to (1R, 2S)-Norephedrine.

This study shows that amylin aggregates faster on fibrillar collagen, leading to β-cell death and dysfunction, which accelerates diabetic progression.

This study identifies remotely located residues and conformational dynamics as regulators of kinetic properties in homologous glutamate dehydrogenases.

This paper reports the rational design of β-glucosidase mutants with improved glucose tolerance and catalytic efficiency for bioethanol production.

This paper engineers β-glucosidases to improve glucose tolerance by analyzing structural changes and mutations that enhance catalytic efficiency and stability.

This study characterizes the structure and function of Aspergillus oryzae exo-β-(1,3)-glucanase, revealing substrate binding mechanisms and insights for industrial enzyme engineering.

This study investigates the structure and inhibition mechanism of TgASP5, identifying potential inhibitors for developing therapeutic strategies against toxoplasmosis.