Ravikant Piyush

Direct CDK1 engagement underlies carbaryl-induced genotoxic cell cycle arrest

This study identifies CDK1 as a direct target of carbaryl, explaining its genotoxic effects and tissue-specific cytotoxicity in renal and cervical cells.

Endosulfan rewires GSK3β to disrupt primary cilia-dependent Hedgehog signalling

This study shows endosulfan disrupts Hedgehog signaling by altering GSK3β activity, leading to ciliopathy-like effects in mice and linking to human reproductive disorders.

Conformational activation of GSK3β by an environmental toxicant suppresses hedgehog signalling

This study shows endosulfan, a pesticide, suppresses hedgehog signaling by activating GSK3β and repressing GLI-regulated genes, mimicking genetic ciliopathies.