Yinyin Wang

This study shows NOK promotes breast cancer by enhancing EGFR signaling through direct interaction and phosphorylation of downstream proteins like STAT3, STAT5, and Erk1/2.

Herb-CMap identifies bioactive ingredients in herbal medicine by integrating gene perturbation data with a random walk algorithm, revealing molecular mechanisms of action for treating cough variant asthma.

This study investigates the role of TIE1 and its interaction with TIE2 in venous development, finding that TIE1 restricts angiogenic sprouting to coordinate vein formation.

This study introduces a gene essentiality signature to predict drug mechanisms of action and target interactions, showing improved accuracy over existing methods.

This paper introduces a drug repurposing method using chemical and genomic data to score compounds for 674 cancer types and other diseases, with results matching ongoing clinical trials.

MICHA is a pipeline that FAIRifies chemosensitivity assays by automatically annotating compounds, samples, reagents, and data processing methods, enabling interoperable and reusable drug screening data.

This study uses a network-based method to quantify interactions in TCM herb pairs, finding that frequently used pairs have shorter network distances, suggesting therapeutic effects through protein interactions.