Nicolas Guyon

This paper introduces a method to control endogenous nicotinic receptors in mice using light-activated drug release, revealing circuit-specific effects previously hidden by systemic administration.

This study maps the prefrontal cortex's functional organization by analyzing single neuron activity in awake mice, revealing that activity patterns align with hierarchy rather than cytoarchitecture.

This study shows that the interpeduncular nucleus (IPN) regulates nicotine reward by modulating VTA neuron activity through β4-containing nAChRs.

The paper shows nicotine inhibits amygdala-projecting dopamine neurons via a VTA-NAc feedback loop, leading to anxiety.

This study shows that trkB signaling is critical for adult parvalbumin interneuron function and prefrontal network dynamics in mice.

The paper shows that reduced synchrony in PV interneurons and excitatory neurons increases broadband gamma power, and that this effect differs between genetic PV deficiency and ketamine-induced changes.